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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S2
All Species:
13.33
Human Site:
T111
Identified Species:
22.56
UniProt:
P20042
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20042
NP_003899.2
333
38388
T111
E
S
D
V
Q
E
P
T
E
P
E
D
D
L
D
Chimpanzee
Pan troglodytes
NP_001092026
333
38354
T111
E
S
D
V
Q
E
P
T
E
P
E
D
D
L
D
Rhesus Macaque
Macaca mulatta
XP_001105021
327
37615
T111
E
S
D
V
Q
E
P
T
E
P
E
D
D
L
D
Dog
Lupus familis
XP_534387
333
38269
A111
E
S
D
I
Q
E
P
A
E
P
E
D
D
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q99L45
331
38074
A111
E
S
D
A
Q
E
P
A
E
P
E
D
D
L
D
Rat
Rattus norvegicus
NP_955412
333
38225
A111
E
S
D
A
Q
E
P
A
E
P
E
D
D
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510012
334
38349
A112
E
S
D
V
P
E
P
A
E
P
E
D
D
L
D
Chicken
Gallus gallus
NP_989928
334
38418
V112
E
G
D
A
P
E
V
V
E
P
E
D
D
L
D
Frog
Xenopus laevis
NP_001090286
332
38131
S109
E
G
E
V
Q
E
A
S
E
S
Q
E
D
D
G
Zebra Danio
Brachydanio rerio
NP_997840
327
37446
Q110
E
T
E
P
S
D
T
Q
E
N
D
D
F
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P41375
312
35199
D121
K
S
K
K
K
E
L
D
E
L
F
A
D
Q
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21230
250
27561
M100
L
T
L
V
Y
Q
V
M
K
D
K
N
P
D
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q41969
268
30644
Y107
G
I
V
L
Q
Q
R
Y
P
W
E
G
S
E
R
Baker's Yeast
Sacchar. cerevisiae
P09064
285
31556
K113
D
N
V
D
A
E
S
K
E
G
T
P
S
A
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
98.1
N.A.
95.5
96.6
N.A.
96.7
94.3
87.6
77.7
N.A.
58.2
N.A.
45.3
N.A.
Protein Similarity:
100
99.6
98.1
99.4
N.A.
98.1
98.5
N.A.
98.1
96.7
92.1
87.3
N.A.
69.9
N.A.
56.7
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
86.6
66.6
40
20
N.A.
26.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
86.6
66.6
66.6
46.6
N.A.
40
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.2
39.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
54.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
8
0
8
29
0
0
0
8
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
58
8
0
8
0
8
0
8
8
65
72
15
58
% D
% Glu:
72
0
15
0
0
79
0
0
86
0
65
8
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
8
% F
% Gly:
8
15
0
0
0
0
0
0
0
8
0
8
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
8
8
8
0
0
8
8
0
8
0
0
0
0
% K
% Leu:
8
0
8
8
0
0
8
0
0
8
0
0
0
58
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
8
0
8
0
0
8
% N
% Pro:
0
0
0
8
15
0
50
0
8
58
0
8
8
0
0
% P
% Gln:
0
0
0
0
58
15
0
8
0
0
8
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% R
% Ser:
0
58
0
0
8
0
8
8
0
8
0
0
15
0
0
% S
% Thr:
0
15
0
0
0
0
8
22
0
0
8
0
0
8
0
% T
% Val:
0
0
15
43
0
0
15
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _